New compounds found in tobacco that can produce highly efficient low-toxic biological pesticides

According to the Chinese Academy of Agricultural Sciences, the Institute of Tobacco Research Institute ’s Plant Functional Ingredients Comprehensive Utilization Innovation team has found prenyl indoles with significant bacteriostatic, insecticidal, less toxic effects in tobacco endophytic fungi. Compounds provide template compounds for the research development of highly efficient low-toxic biological pesticides with independent intellectual property rights. Related research results were published online in the Journal of Agricultural Food Chemistry.

Zhang Peng, deputy researcher of the Tobacco Institute of the Chinese Academy of Agricultural Sciences, said that while traditional chemically synthesized pesticides bring huge economic benefits to agricultural production, they also cause harm to ecosystems; microbial source pesticides are highly efficient, low toxicity, environmentally friendly The role in the prevention control of plant diseases insect pests has become increasingly prominent.

The team isolated 6 prenyl indole metabolites a tobacco-derived endophytic fungus, Elder Fusarium oxysporum TE-6L, including 2 new structural compounds. Studies have shown that this class of metabolites can significantly inhibit a variety of plant pathogens have insecticidal activity; at the same time, the team used zebrafish embryos as a model to evaluate the developmental toxicity of this compound for the first time. These compounds have novel structure, remarkable activity low toxicity, have the potential to be developed into new biological pesticides.